Evaluation of using absolute vs. relative base level when analyzing brain activation images using the scale-space primal sketch

نویسندگان

  • Mikael Rosbacke
  • Tony Lindeberg
  • Per E. Roland
چکیده

A dominant approach to brain mapping is to de ne functional regions in the brain by analyzing images of brain activation obtained from positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). This paper presents an evaluation of using one such tool, called the scale-space primal sketch, for brain activation analysis. A comparison is made concerning two possible definitions of the scale-space signi cance measure, where local contrast is measured either relative to a local or global reference level. Experiments on real brain data show that the global approach with absolute base level gives a higher signi cance to small blobs superimposed on larger scale structures, than a local approach with relative base level, whereas the signi cance of isolated blobs largely remains una ected. The global approach also has a higher degree of correspondence to a traditional statistical method. Relative to previously reported works, the following two technical improvements are also presented: (i) A post-processing tool is introduced for merging multiple blob responses to similar image structures. This simpli es automated analysis from the scale-space primal sketch. (ii) A new approach is introduced for scale-space normalization of the signi cance measure, by collecting reference statistics of residual noise images obtained from the general linear model.

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تاریخ انتشار 1999